The alarming practice of adding chemicals to public water supplies to control fertility has been proposed by influential figures in science. In 1962, Francis Crick, a Nobel Prize recipient, suggested introducing a sterilizing chemical into water supplies to prevent uncontrolled reproduction, with only licensed individuals receiving an antidote. Similarly, John P. Holdren, a science advisor, wrote in 1977 about the controversial idea of adding sterilants to drinking water or staple foods as a method of involuntary fertility control. Research indicates that fluoride, a chemical present in over 70% of the U.S. water supply, is linked to infertility among other severe health issues. This neurotoxic substance, also a component in military nerve gas, disrupts basic bodily functions and lowers fertility rates, posing a significant threat to reproductive health.

The Bill and Melinda Gates Foundation has been linked to initiatives that raise concerns about population control through reproductive health services. In a 2010 TED Talk, Bill Gates suggested that with effective vaccines, health care, and reproductive health services, global population growth could be reduced by 10 to 15 percent, as the world heads toward nine billion people. In a 2003 interview, he highlighted his focus on population issues, clarifying it as reproductive health, and noted his father's significant role in Planned Parenthood. The Foundation has funded Planned Parenthood both in America and globally, supporting abortions and vaccines that have been associated with sterilization in third-world populations. Obianuju Ekeocha, author of Target Africa, states that Melinda Gates aims to impact 69 of the poorest countries, mostly in sub-Saharan Africa, with nearly $5 billion to reduce fertility among African women under the guise of liberation. The Gates Foundation's efforts in population control are now promoted as Gender Equality or women's rights. Over the past two decades, vaccines funded by the Foundation have reportedly caused sterilization, disability, and death to thousands in the third world, leading to accusations of ruthless and immoral practices from Nelson Mandela's former senior economist, who described affected populations as guinea pigs for drug makers.

Fertility has been declining rapidly since the 1950s in all countries of the world, with the start of this change coinciding with the introduction of the first mass vaccination programs. In the UK, for instance, a mass DPT vaccine campaign began in 1947, followed by polio and diphtheria vaccines on a mass scale in 1958 for all people under 15 years old. Vaccines contain ingredients potentially damaging to fertility, such as detergents like Triton X100, also known as octoxynol-10, a known spermicide used in experiments to strip sperm of their fertilizing capability. Studies, including one from 1997 in The Journal of Reproduction and Fertility, list Triton X100 among the most potent spermicides for achieving complete stripping of human sperm. This ingredient, along with polysorbate 80, which also causes infertility, is present in many vaccines, including the fluarix influenza virus vaccine. Scientists from the World Intellectual Property Organization, part of the United Nations, are developing vaccines specifically to restrain fertility as a method of contraception, with polysorbate 80 as a preferred ingredient due to its known ability to cause infertility. The Vaccine Adverse Events Reporting system records numerous incidents of miscarriages among teenage girls and women injected with Gardasil while pregnant. In 2010, reports indicated that the U.S. birth rate fell for the second year in a row, dropping 2.6% that year, with a decline of 5.5% since 2007 and a staggering 19% since 1990. Research objectives from the World Health Organization's task force on Vaccines for Fertility Regulation aim to develop vaccines that inhibit fertilization and disrupt implantation, with trials showing these vaccines can elicit antibodies conferring an anti-fertility effect in fertile women. Vaccinations have been used as carriers for infertility compounds, often shipped as foreign aid to developing nations for birth control without consent, as seen in the mid-1990s with tetanus and polio vaccines in Mexico, the Philippines, and Nigeria, which were found to contain compounds blocking pregnancy. Additionally, GMO foods and vaccines, including edible versions in corn and bananas, are being researched and developed with infertility genes, further contributing to potential depopulation strategies.