To this day, a perpetual conflict exists between Ishmael's offspring and Isaac's offspring, with the Ishmaelites determined to wipe Israelites off the earth.

Esau was prophesied to be the father of a nation, Edom, and the Bible gives us plenty of clues about the character of his descendants.

The King of the South (Daniel 11:40) might be a confederation of Arabic/Islamic nations continually at war with the people of Israel.