Physical sin encompasses transgressions of moral law committed in the flesh, such as sexual immorality, gluttony, drunkenness and stealing. Gnostics separated these acts from sins of the spirit like rebellion, pride, vanity and greed, which they termed anomia, while labeling physical acts hamartia. They concluded that God overlooks hamartia because the flesh is irredeemable and inconsequential to salvation. The apostle counters that hamartia and anomia are identical, so any violation of God's law, whether physical or spiritual, constitutes sin. God commands avoidance of pork and shellfish; consumption of these foods is therefore sin. God forbids sexual immorality; participation in it is sin. Breaking laws of physical health through lack of exercise, poor nutrition, unhygienic practices or bodily abuse defiles the temple of the Holy Spirit and brings judgment. Such conduct produces spiritual effects because all sin originates in the mind and can degenerate character. Christ's sacrifice removes all hamartia without regard to classification and covers physical sins equally with spiritual ones. Forgiveness of iniquity is linked directly to healing of disease, demonstrating that physical violations fall under the same redemptive provision as every other transgression.

Physical sin consists of defiling the temple of God by breaking physical laws that govern the human body. Such sins include overeating, excessive drinking, and gluttony. These acts receive the same condemnation as other transgressions because the body constitutes the sanctuary of the Holy Spirit. God requires that His people glorify Him in both body and spirit since the entire sacrifice of Jesus Christ covers physical and spiritual dimensions alike. Breaking physical laws produces sickness, pain, or death just as surely as breaking spiritual laws produces similar penalties. Stewardship of the body therefore demonstrates loyalty to the Creator and submission to all of His statutes, judgments, and precepts. These laws remain in force perpetually and apply equally to every person. Failure to keep them results in the diseases once visited upon Egypt. Gluttony functions as a form of idolatry that places physical appetite above obedience to God and prevents effective service in His Kingdom.

The term physical sin never appears in the Bible. Eating things God designed as unclean is simply sin. It does not call it physical sin. It is simply sin. The term translated sin simply means to miss the mark, to fall short, to go off the path. When one eats something that God designated one should not, one falls short of the ideal.