The rise of America, believed to descend in great part from the patriarch Joseph, particularly his son Manasseh, is seen as fulfilling physical prophecy. Jacob declared to Joseph that his two sons, Ephraim and Manasseh, would become great nations, with one being a great commonwealth of nations and the other a great single nation, and the elder would serve the younger. The founding of this nation is considered no mere chance, with many twists and turns in history guided by God Himself to bring about His purpose. Despite these blessings and guidance, this nation, like others, is not seen as God's country, for it is made up of men whom the Father has not called, and thus it remains cut off from Him.

A related matter concerns the tribe of Ephraim. Some have thought that this tribe is not mentioned among the 144,000, but Ephraim is indeed included. Both the tribe of Manasseh and the tribe of Joseph are listed. Ephraim and Manasseh were the two sons of Joseph. Since Manasseh is one of the two tribes descended from Joseph, the tribe of Joseph mentioned must refer to Ephraim. From this, it is clear that Ephraim, as the leading tribe of the house of Joseph, sometimes bore the name Joseph.

The United States and Britain share a deep bond known as the Special Relationship, rooted in a connection that extends beyond politics or language. This bond traces back to the Israelite tribe of Joseph, which Jacob, by divine inspiration, divided into the half-tribes of Ephraim and Manasseh, naming them as his heirs. Jacob prophetically described Ephraim as a multitude of nations and Manasseh as a great nation, reflecting the British Commonwealth, once an empire, and the United States of America, respectively. Their Special Relationship thus represents a brotherhood with origins stretching back nearly four millennia to Joseph's prominence in Egypt.

In the prophecy of Hosea, Ephraim and Manasseh are highlighted as significant representations of Israel's unfaithfulness and the consequences that follow. Ephraim, often used interchangeably with Israel, exemplifies the worst of the nation's rebellion against God, turning away from Him more severely than any other tribe. This tribe stands as a symbol of the broader spiritual decline among God's people, embodying their rejection of His covenant. Manasseh, alongside Ephraim, is considered among the descendants of Israel, reflecting the national identity that has strayed into sin and secularism. Both are part of the Israelitish nations that face judgment for their disobedience, as seen in their historical and ongoing moral and spiritual failures. God's omniscience pierces through their attempts to hide, exposing their sins and their futile efforts to seek Him without true repentance. Despite their waywardness, God's love persists, as He sends warnings and chastisements, likened to a moth and a lion, to draw them back to Him. Ultimately, there remains a hope for deliverance and healing for Ephraim, Manasseh, and all of Israel, contingent upon genuine confession, repentance, and a return to God's ways, with the promise of His freely given love awaiting their restoration.