The veneer of civility that covers civilization is thin, hardly able to conceal our carnal nature. That nature turns violent seemingly at the drop of a hat.
Paul describes the latter times, when people will behave like spoiled brats, cursing, looting, and showing no self-control—all happening today.
We face the same kind of pressures and stress that Timothy faced, with perilous times ahead of us, threatening the existence of the nation and the church.
Nadab and Abihu, Ananias and Sapphira, and Uzzah, all aware of the penalties for their actions, rebelled against God's clear and unambiguous instructions.