The sour wine mingled with gall offered to Jesus before His crucifixion (Matthew 27:34) fulfilled David's prophecy in Psalm 69:21. Easton's Bible Dictionary describes it as soldiers' vinegar made bitter with wormwood or a similar substance, customarily given as a pain reliever to the crucified. The soldiers' cruelty and mockery, however, make an act of mercy illogical, and the gall, being a poison as well as a desensitizing drug, may have been meant to hasten death. Jesus refused it, and the Greek geuomai may even mean He never actually tasted it; a taste is not a drink. Five reasons for His refusal are suggested: its disgusting taste, the mockery behind the offer, His need to endure the pain with a clear mind and body, His vow in Matthew 26:29 not to drink the fruit of the vine until the Kingdom, and the fact that His blood, the antitype of the once-pure wine, had been soured by the sins of the world laid on Him in Gethsemane. Lamentations 3:15, 19 speaks prophetically of this wormwood and gall. If the sour wine pictured His tainted blood, the gall may symbolize the water that flowed from His pierced side. The gall is thus part of the bitter cup the Father gave Him to drink.

The source never mentions gall directly. Its nearest touch on the topic is the sour wine offered to Jesus on the cross. In Matthew 27:46-50 a sponge filled with sour wine is raised to Him on a reed, and in John 19:28-30 He says "I thirst" so that Scripture, specifically Psalm 69:21, might be fulfilled. Jesus accepts the wine, then declares "It is finished," bows His head, and gives up His spirit. The source treats the drink as evidence that He stayed lucid and in command through His suffering, deliberately recalling prophecies and laying down His life voluntarily rather than having it taken from Him.

Gall appears in the source as part of the drink offered to Jesus just before the crucifixion. Matthew 27:34 records sour wine mixed with gall, and Mark 15:23 mentions myrrh. Jesus tasted it and refused. Gall was very bitter and acted as an anesthetic, an intoxicating drink that dulled the sense of suffering, and it was usually given to the crucified as a kindness. Jesus declined it because He did not want His mind dulled or to feel removed from the pain He bore as the Sin-bearer. For Him the drugged drink was meant as an insult. Gall also ties to prophecy: Psalm 69:21 says, "They also gave Me gall for My food, and for My thirst they gave Me vinegar to drink." Since the gall had already been offered, but no vinegar had yet been given for His thirst, Jesus cried "I thirst" so that the last remaining prophecy might be completed. He then received the sour wine and said "It is finished." This shows that He actively worked to fulfill Scripture, not merely waiting for it to unfold.