In the evaluation of the church in Pergamos, Jesus Christ introduces Himself as the Judge with a sharp two-edged sword, signifying His authority to see sin among the members and threaten punishment. He notes that Pergamos lies where Satan's throne is and where Satan dwells, indicating a strong presence of satanic influence and persecution in the city. Despite being no more wicked than other cities of the time, Pergamos is marked by the Devil's work, particularly through loyalty and fanaticism to the Roman emperor cult. Jesus acknowledges the difficult circumstances faced by the Pergamenes, including persecution and satanic influence, and commends them for holding fast to His name under such trying conditions. However, He criticizes their tolerance of evil and calls for repentance and growth to align more closely with His standards. The lesson conveyed is that where criticism, persecution, and pride are prevalent, Satan spends a great deal of time, taking pleasure in accusation and negativity, and such attitudes must be diligently avoided by the faithful.

The city of Pergamos is described as a place where Satan's throne is located. This reference might allude to the city's conical mountain, which resembles a throne when viewed from the south. Additionally, atop this citadel, a massive altar to Zeus was built, which itself looks like a great throne from a distance. This altar, possibly also dedicated to Athena, could be what Christ refers to as Satan's throne. Furthermore, the city's extensive pagan religious activity, including temples dedicated to various gods and the presence of the Imperial cult, suggests that Pergamos was a seat of Roman paganism in Asia, where Satan had great influence. The Christians in Pergamos were surrounded by this environment, constantly pressured to conform to these pagan practices for religious, cultural, and economic reasons.

In Pergamos, the church of God is situated right where Satan's throne is, amidst a society that is described as totally corrupt and Satanic. This environment has led the church to tolerate sin, much like Lot tolerated the sin of Sodom. They allow idolatry and sexual immorality to be practiced among them, showing a compromise with the corrupt culture surrounding them.