In the year that King Uzziah died, Isaiah beheld a vision of the Lord sitting on a throne, high and lifted up, with the train of His robe filling the temple. Above the throne stood seraphim, each with six wings: two covering their faces, two covering their feet, and two for flying. These fiery angelic beings, whose name in Hebrew means flames, cried out to one another, proclaiming, "Holy, holy, holy is the Lord of hosts; the whole earth is full of His glory!" The powerful voices shook the doorposts, and the house was filled with smoke, likely to shield Isaiah from the full glory of God. Overwhelmed, Isaiah exclaimed, "Woe is me, for I am undone! Because I am a man of unclean lips, and I dwell in the midst of a people of unclean lips; for my eyes have seen the King, the Lord of hosts." In response, one of the seraphim flew to him, holding a live coal taken from the altar with tongs, and touched his mouth, declaring, "Behold, this has touched your lips; your iniquity is taken away, and your sin is purged." Cleansed and sanctified by this act, Isaiah heard the voice of the Lord asking, "Whom shall I send, and who will go for Us?" Isaiah responded with readiness, saying, "Here I am! Send me." The Lord then commissioned him to go and tell the people to hear but not understand, to see but not perceive, dulling their hearts and closing their ears and eyes, lest they turn and be healed, as a consequence of their persistent rejection of God. Thus, Isaiah was directly set up by God as a prophet, transformed from despair to willingness through divine grace and purification.

In the vision described in Isaiah 6, the prophet Isaiah witnessed the Lord sitting on a throne, high and lifted up, with the train of His robe filling the temple. Above the throne stood seraphim, fiery angelic beings with six wings, two covering their faces, two covering their feet, and two used for flying. These seraphim cried out to one another, proclaiming, "Holy, holy, holy is the Lord of hosts; the whole earth is full of His glory!" The power of their voices shook the posts of the door, and the house was filled with smoke, likely to shield Isaiah from the full glory of God. Overwhelmed by this sight, Isaiah exclaimed, "Woe is me, for I am undone! Because I am a man of unclean lips, and I dwell in the midst of a people of unclean lips; for my eyes have seen the King, the Lord of hosts." In response, one of the seraphim flew to him with a live coal taken from the altar, touching his mouth and declaring, "Behold, this has touched your lips; your iniquity is taken away, and your sin is purged." Following this cleansing, Isaiah heard the voice of the Lord asking, "Whom shall I send, and who will go for Us?" Isaiah responded with readiness, saying, "Here I am! Send me." The Lord then commissioned him to go and tell the people to hear but not understand, to see but not perceive, dulling their hearts, ears, and eyes so they would not return and be healed, as a consequence of their persistent rejection of God. Thus, Isaiah was set up as a prophet directly by God, after being cleansed and sanctified for his mission.

In the vision described, the calling of Isaiah provides a poignant parallel to the scene of profound worthiness and divine commissioning. Isaiah, in his vision, beholds the Lord seated on His throne, surrounded by seraphim who praise God (Isaiah 6:1-2). Overwhelmed by the sight, Isaiah is struck by his own uncleanness and unworthiness to gaze upon the Lord of Hosts (Isaiah 6:5). Yet, a seraph touches his mouth with a coal, purging his sin and removing his iniquity, thus making him worthy for divine use (Isaiah 6:6-7). Following this cleansing, Isaiah hears the Eternal's call, asking, "Whom shall I send, and who will go for Us?" Isaiah responds eagerly and receives his commission to deliver a message to Judah (Isaiah 6:8). This event underscores the theme of worthiness through divine purification, highlighting the transformative power of God's intervention to prepare His servants for significant tasks.