Angels do not marry, so the "sons of God" who took wives in Genesis 6:1-4 cannot have been angels who fathered a race of giants. Jesus says plainly that in the resurrection humans "neither marry nor are given in marriage, but are like angels of God in heaven" (Matthew 22:30). Angels are ministering spirits (Hebrews 1:13-14), while women are human, so the two are different kinds of being. From creation God established that each kind reproduces only after its own kind (Genesis 1), and different species cannot breed. The context confirms this, since God speaks of fleshly mankind when He says His Spirit will not strive with man forever. Although angels are sometimes called sons of God (Job 1:6; 38:7), the phrase can also mean regenerated Christians or all humans, who are God's children by creation through Adam. The sons of God in Genesis 6 were therefore ordinary men who had forsaken God and intermarried in defiance of His law. Giants existed before and after these unions and throughout history, so they need not be the offspring of such marriages.

Angels do not marry or reproduce, so they cannot be the fathers of the mighty men of Genesis 6:4. Jesus says in Mark 12:25 that in the resurrection human beings will be like the angels in heaven, who neither marry nor are given in marriage. That statement contradicts the view that the sons of God in Genesis 6:2 were angels who married the daughters of men. Genesis establishes that each created kind reproduces only after its own kind, just as cats mate only with cats and dogs with dogs. Humans are fleshly beings formed from the dust, while angels are spirits, according to Psalm 104:4 and Hebrews 1:14. Beings of two distinct kinds cannot mate and reproduce, so angels cannot impregnate mortal women. Even if they could, the offspring would be strange hybrids, yet the context calls the children men, mighty men of renown. The phrase "came in to" is the ordinary Old Testament expression for human sexual intercourse, which excludes any spiritual or magical conception. Angels were also created as servants, not as potential members of God's Family, and hybrid offspring would insert an alien element into God's plan. The sons of God in this passage were the godly descendants of Seth, who married the daughters of Cain's line.

Angels do not marry, cannot have sexual relations, and according to Scripture cannot die. This truth stands in direct contrast to depictions in which angels desire to become human and enter marriage. Holy angels have no such inclination, whereas any desire to assume human form would belong only to fallen angels. The point emerges from Jesus' statement in Luke 20:34-36 that the sons of this age marry and are given in marriage, yet those counted worthy to attain the resurrection from the dead neither marry nor are given in marriage, for they are equal to the angels and are sons of God. The passage thereby identifies angels as spirit beings whose nature excludes the marital and reproductive relations that belong to physical humanity. This distinction reinforces the broader chronology of angelic creation and function: angels were formed as individual spirit servants before the recreation of the earth, remained loyal or fell according to their own choices, and now minister under God's direction to those who will inherit salvation. Because they occupy a different order from resurrected humans, they neither require nor possess the capacity for marriage, underscoring their appointed role as ministering spirits rather than participants in the family relationships reserved for the children of God.