The Scriptures indicate that the giants of Genesis 6:4 died out during the worldwide Flood that God sent to destroy all flesh upon the earth. These giants, being a natural genetic variation of human beings, perished along with the rest of the earth's population, except for Noah and his family. Since Noah was of a smaller stature, most of his descendants were similar in size, but some genes for producing giants survived through the wife of Ham, one of Noah's sons. Consequently, a number of the sons of Canaan, a son of Ham, were giants. Moses records that God destroyed the giants who dwelt in Ammon to allow the children of Lot to possess the land. Those giants, apparently descended from Canaan through a man named Anak, eventually became extinct, with King Og of Bashan being the last of them to inhabit Palestine east of Jordan. Another notable giant, Goliath of Gath, was killed by the young David with a sling stone. Goliath's brother and sons, also men of great stature, were all killed by David and his men. Both before and after the Flood, God was directly involved in the destruction of these giant men.

The term 'Nephilim' appears in Genesis 6:4, associated with the extreme wickedness of that era. Nephilim, an obscure plural noun left untranslated in English Bibles, literally indicates a feller, someone who knocks things over, but through usage, it is more frequently thought to indicate giants of some kind. This is supported by the verse describing them as mighty men and heroes, personalities who attracted significant attention and large followings. They lived not only before the Flood but also after it, showing they were not confined to a single period. It is clear that they were completely human beings, not the offspring of demons and human women, as God's word states each kind reproduces only after its kind, making such reproduction impossible. The verse refers to them as sons of God, where 'God' is translated from 'elohim,' a term not exclusively used for the Creator but also for human judges and magistrates, indicating humans in positions of authority. These Nephilim are remembered in Hebrew history as greatly feared tyrants, dominating as leaders of cities and nations, akin to figures like Nimrod. Their giantism is partly drawn from large physical stature but more so from being dominant leaders with vast influence. Modern translators favor the term 'giant' to suggest persons who dominate in their field, excelling over others, much like notable figures in economics, politics, or sports who attract followers through their achievements and personalities. The Nephilim are seen as teaching personalities who draw attention with anti-God teachings, deceptively influenced by satan, misleading humanity. As wickedness reigns supreme, mirroring the time before the Flood as Jesus prophesied, the Nephilim are poised to play a major role once again in a world where the Beast and his forces challenge God, supported by the mechanical, electronic, and nuclear means to destroy life, combined with human leadership and will.

In Genesis 6:4, the nephilim are designated as leaders who rebelled violently against God and His way of life. They existed both before and after the Flood, being most prominent before it, and are also mentioned in Numbers 13:33. Biblically, the nephilim before and after the Flood shared only their large stature, with no genetic relationship between them, as all humans post-Flood descend from Noah and his family, who were not their parents. The term nephilim seems to indicate a warrior class of bullies within communities, often defined as such in Hebrew dictionaries. They were considered great, not for social benefit or good leadership, but for leading people's base desires toward shortsighted, anti-God excitement, acting as trendsetters who encouraged the wickedest aspects of human nature. Labeled as sons of God in Genesis 6:4, this term does not imply divinity but refers to mere human mortals, as elohim in Scripture can denote human leaders or magistrates rendering decisions believed to be God's judgment. The nephilim were popular, anti-God leaders among the people, violent and tyrannical, inflicting great damage upon mankind, so significant that God was moved to mention them. Their destructive influence, akin to historical tyrants, affected millions, not only through political and military power but also through educational and philosophical teachings that precipitated anti-God purpose and outlook across various realms of life.