After Cain slew his brother, he went out from the presence of the Lord. He traveled to the land of Nod on the east of Eden. There he married a woman, had a son and additional children, and founded a society in opposition to God. His actions show that he distanced himself from God as far as he could. The passage tells of an ungodly world that sprang from him and his turning his back on Eden. It is based on physical accomplishments, as exemplified by Cain's descendants. Moses relates the first example of polygamy when Lamech took two wives, and later the same unrepentant descendant of Cain also commits murder, apparently in revenge. Lamech's sons were quite accomplished. Jabal originated nomadic herding of livestock. Jubal invented harp and flute music. Tubal-Cain instructed craftsmen in working with bronze and iron. In other words, they were their time's talented and famous men, but they rose to prominence in a godless and amoral society. These sons of men, the descendants of Cain, were distinct from the sons of God, the descendants of Seth. It appears that none of Cain's descendants survived the Flood. It was their sinful lifestyle that God had to destroy to preserve the human race. The descendants of Seth saw the beauty of the daughters of Cain. They married and had children with them, and their offspring became great and mighty men in an evil world. God soon decided to destroy the men He had created because their wickedness had grown so great that repentance was all but impossible for them.

The descendants of Cain formed a corrupted line upon the earth. Cain's offspring did what was right in their own eyes. Those of Cain went off toward the east and built their own cities. They became wicked and corrupt because they totally left God out of the picture. God traces the family of Cain beginning in Genesis 4:16 and continues through Cain's line down through the sons of the evil Lamech. Cain's line was worse than the line of Seth. The males of Seth's line noticed the beauty of the women of Cain's line and began to intermarry. The bad ways of Cain's line always corrupted the good. The children of these unions followed the wicked mothers and maternal parents rather than the righteous fathers. Cain's descendants contributed to the corruption that eventually touched the whole of humanity before the Flood.

Cain went out from the presence of the Lord. Cain's son Lamech marries two women thus signaling a further departure of Cain's family from God's way and Lamech is following the same anti God path as his father Cain. Lamech too had already murdered another family member even as Cain his father did. The Cain-Lamech line produced nobody noteworthy in regard to righteousness. The sons of God from the line of Seth took wives from everywhere including the Cain-Lamech line. The seed of Satan are spiritual children that he influences freely and thus bears his characteristics like Cain and Lamech.